Jun Chen

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Christin Tse, Alexander R. Shoemaker, Jessica Adickes et al. · Cancer Research · 2008 · 1.9K citations · Full text

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Darren C. Phillips, Michael J. Mitten, Erwin R. Boghaert et al. · Science Translational Medicine · 2015 · 530 citations · Full text

Cancer Therapy, Chemoprevention Strategy, Bcl-2/bcl-xl/bcl-w Inhibitor Abt-263 +20

Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

Lin‐Li Lv, Feng Ye, Min Wu et al. · Cell Death and Differentiation · 2019 · 415 citations · Full text

Renal Pathology, Immunology, Renal Inflammation +17

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Chaohong Sun, Mengli Cai, Angelo Gunasekera et al. · Nature · 1999 · 342 citations

Nmr Structure, Apoptosis, Molecular Biology +2

ALARM NMR:  A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens

Jeffrey R. Huth, Renaldo Mendoza, Edward T. Olejniczak et al. · Journal of the American Chemical Society · 2004 · 228 citations

Drug Target, Hit Identification, Thiol Reactivity +18