Discovery of a proteinaceous cellular receptor for a norovirus

Robert C. Orchard, Craig B. Wilen, John G. Doench, +8

Science

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

Craig B. Wilen, Sanghyun Lee, Leon L. Hsieh, +20

Science

Expression of <i>Ifnlr1</i> on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus

Megan T. Baldridge, Sanghyun Lee, Judy J. Brown, +5

Journal of Virology

Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ

Harshad Ingle, Sanghyun Lee, Teresa L. Ai, +12

Nature Microbiology

Enteric PathogensImmunodeficiency Confers ProtectionHuman RetrovirusPathogenesisViral Pathogenesis +10

Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases

Scott B. Biering, Jayoung Choi, Rachel A. Halstrom, +12

Cell Host & Microbe

Viral ReplicationImmunologyAntiviral ResponseVirologyVirus-host Interaction +4

Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine

Sanghyun Lee, Craig B. Wilen, Anthony Orvedahl, +7

Cell Host & Microbe

Viral ReplicationPathogenesisViral PathogenesisImmunologyVirology +8

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Sanghyun Lee, Hejun Liu, Craig B. Wilen, +11

Cell Host & Microbe

MedicinePathogenesisGastrointestinal VirusVirology

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Jacob A. Van Winkle, Stefan T. Peterson, Elizabeth A. Kennedy, +11

eLife

Disruption of Type III Interferon (IFN) Genes <i>Ifnl2</i> and <i>Ifnl3</i> Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response

Stefan T. Peterson, Elizabeth A. Kennedy, Pamela H. Brigleb, +8

Journal of Virology

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Anthony Orvedahl, Michael R. McAllaster, Amy Sansone, +12

Proceedings of the National Academy of Sciences