Man Zhang

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Wei Qi, Homan Chan, Lin Teng et al. · Proceedings of the National Academy of Sciences · 2012 · 542 citations · Full text

Selective Inhibition, Tumor Biology, Methyl Group +15

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 313 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

Tahsin Stefan Barakat, Florian Halbritter, Man Zhang et al. · Cell stem cell · 2018 · 221 citations · Full text

Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation

Jing Jiang, Wenjian Lv, Xiaoying Ye et al. · Cell Research · 2012 · 145 citations · Full text

Developmental Biology, Genomic Stability, Genetics +8

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy

Ying Huang, Jeff Zhang, Zhengtian Yu et al. · Journal of Medicinal Chemistry · 2017 · 100 citations · Full text