Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

Koichi Matsuo, Deborah L. Galson, Zhao Chen, +8

Journal of Biological Chemistry

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

Yumin Hu, Weiqin Lu, Gang Chen, +11

Cell Research

MitophagyBiochemistryMitochondrial FunctionMitochondrial DysfunctionNatural Sciences +9

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

Yunfei Zhou, Yan Zhou, Takashi Shingu, +6

Journal of Biological Chemistry

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

Hiromichi Ebi, Ryan B. Corcoran, Anurag Singh, +10

Journal of Clinical Investigation

Pi3k SignalingExert Dominant ControlCell DeathTumor BiologySignaling Pathway +15

Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer

Takeshi Shimamura, Zhao Chen, Margaret Soucheray, +12

Clinical Cancer Research

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i> -Mutant Lung Cancer

Yan Liu, Kevin Marks, Glenn S. Cowley, +37

Cancer Discovery

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

Jiamei Lu, Jianhua Shi, Manxiang Li, +9

Life Sciences

FibrosisUrologyRenal FunctionPhysiologyMouse Renal Fibroblasts +11

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

Haikuo Zhang, Christine F. Brainson, Shohei Koyama, +31

Nature Communications

Tumor BiologyTranscriptional RegulationMedicineCancer Cell BiologyLkb1 Inactivation Drives +9

Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells

Alexandros Tzatsos, Polina Paskaleva, Stephania Lymperi, +5

Journal of Biological Chemistry

Inhibition of Mitochondrial Respiration and Rapid Depletion of Mitochondrial Glutathione by β-Phenethyl Isothiocyanate: Mechanisms for Anti-Leukemia Activity

Gang Chen, Zhao Chen, Yumin Hu, +1

Antioxidants and Redox Signaling