Yang Chen

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu et al. · Cancer Cell · 2011 · 2.8K citations · Full text

Molecular Pharmacology, Aldehyde Dehydrogenase, Biochemistry +4

A candidate prostate cancer susceptibility gene at chromosome 17p

Sean V. Tavtigian, Jacques Simard, David H.F. Teng et al. · Nature Genetics · 2001 · 555 citations

Urology, Genetics, Chromosome 17P +3

Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation

Yuying Liu, Xiaoyu Liang, Wenqian Dong et al. · Cancer Cell · 2018 · 500 citations

Ahr Activation, Cancer Immunosurveillance, T-regulatory Cell +10

Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription

Rui Xiao, Jiayu Chen, Zhengyu Liang et al. · Cell · 2019 · 403 citations · Full text

Histone Modifications, Chromatin, Transcriptional Regulation +14

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Yu-Lu Cao, Shuxia Meng, Yang Chen et al. · Nature · 2017 · 312 citations · Full text

Mitochondrial Function, Medicine, Molecular Biology +2