COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Xianwen Ren, Wen Wen, Xiaoying Fan, +87

Cell

Single Cell SequencingMedicineImmunologySingle-cell GenomicsChronic Viral Infection +3

Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation

Peipei Zhang, K. Tsuchiya, Takeshi Kinoshita, +6

Journal of Biological Chemistry

InflammationCytokineAnti-inflammatoryInflammatory DiseaseImmunology +7

Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death

Xiang Li, Peipei Zhang, Zhiyong Yin, +8

Research

ApoptosisImmune RegulationImmunologyCell DeathPathology +26

Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE−/− mice by downregulating the HMGB1-RAGE axis

Ming Liu, Ying Yu, Hong Jiang, +7

Acta Pharmacologica Sinica

InflammationVascular DiseaseCardiovascular DiseaseApoe−/− MiceVascular Inflammation +11

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells

Huabin Ma, Zhoujie Zhu, Huaipeng Lin, +7

Cell Discovery

Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications

Thanutchaporn Kumrungsee, Peipei Zhang, Maesaya Chartkul, +2

Frontiers in Nutrition

NutritionNutritional EpidemiologyImmunologyPublic Health NutritionNutrition Development +20

NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Peipei Zhang, Yifei Liu, Lichen Hu, +6

Science Advances

Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral <em>Candida albicans</em>

Li Zhou, Peipei Zhang, Zhuo Chen, +6

International Journal of Nanomedicine

EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR

Guangxiang Cao, Susan T. Howard, Xiuhua Pang, +4

Microbiology

Molecular RegulationTuberculosis PreventionBacteriologyMolecular BiologyDrug Resistance +20

Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting Mpro and Sepsis in Mice

Ting Xiao, Mengqi Cui, Caijuan Zheng, +12

Inflammation

InflammationMedicinePathogenesisViral PathogenesisAntiviral Drug Development +4