Salma M. Hefny

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments

Salma M. Hefny, Tarek F. El‐Moselhy, Nabaweya Sharaf El-Din et al. · European Journal of Medicinal Chemistry · 2024 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Investigations of Coumarin-Based Thiazoles

Salma M. Hefny, Tarek F. El‐Moselhy, Nabaweya Sharaf El-Din et al. · Journal of Medicinal Chemistry · 2024 · 42 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma

Haytham O. Tawfik, Mohamed M. Saleh, Andrea Ammara et al. · Journal of Medicinal Chemistry · 2024 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations

Moataz A. Shaldam, Maha‐Hamadien Abdulla, Andrea Angeli et al. · Journal of Molecular Structure · 2024 · 20 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fragment-based design and synthesis of coumarin-based thiazoles as dual c-MET/STAT-3 inhibitors for potential antitumor agents

Bassem H. Naguib, Heba A. Elsebaie, Mohamed S. Nafie et al. · Bioorganic Chemistry · 2024 · 13 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17