Haytham O. Tawfik

Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach

Haytham O. Tawfik, Andrea Petreni, Claudiu T. Supuran et al. · European Journal of Medicinal Chemistry · 2022 · 60 citations · Full text

Chemical Biology, Combinatorial Chemistry, Medicinal Chemistry +11

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations

Ahmed A. Al‐Karmalawy, Mohamed S. Nafie, Moataz A. Shaldam et al. · Journal of Medicinal Chemistry · 2022 · 58 citations

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

Moataz A. Shaldam, Hadia Almahli, Andrea Angeli et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2023 · 44 citations · Full text

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments

Salma M. Hefny, Tarek F. El‐Moselhy, Nabaweya Sharaf El-Din et al. · European Journal of Medicinal Chemistry · 2024 · 35 citations · Full text

Medicinal Chemistry, Vitro Biological Assessments, Biochemistry +11

Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights

Heba A. Elsebaie, Eman A. El-Bastawissy, Kamel M. Elberembally et al. · Bioorganic Chemistry · 2023 · 34 citations · Full text