Yoshihisa Nakada

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 <i>H</i> -pyrazolo[3,4- <i>c</i> ]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships

Masato Yoshikawa, Morihisa Saitoh, Taisuke Katoh et al. · Journal of Medicinal Chemistry · 2018 · 115 citations · Full text

Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design

Takeshi Yasui, Takeshi Yamamoto, Nozomu Sakai et al. · Bioorganic & Medicinal Chemistry · 2017 · 38 citations · Full text

Drug Target, Medicine, Rational Drug Design +9

Coenzyme A: Diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets

Toshihiro Yamamoto, Hiroshi Yamaguchi, Hiroshi Miki et al. · European Journal of Pharmacology · 2010 · 33 citations

Obesity, Metabolic Syndrome, Biochemistry +13

An enantioconvergent route to (−)-kainic acid

Yoshihisa Nakada, Tsutomu Sugahara, Kunio Ogasawara · Tetrahedron Letters · 1997 · 31 citations

Enantioconvergent Route, Organic Chemistry, Chemistry +3

Novel acyl coenzyme A (CoA): Diacylglycerol acyltransferase-1 inhibitors: Synthesis and biological activities of diacylethylenediamine derivatives

Yoshihisa Nakada, Thomas D. Aicher, Yvan Le Huérou et al. · Bioorganic & Medicinal Chemistry · 2010 · 28 citations · Full text

Medicinal Chemistry, Biosynthesis, Biochemistry +12