A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Collette K. Hand, Hitoshi Osuga, Yoshiko Yanagisawa, +17

Nature Genetics

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisGeneticsExperimental NeuropathologyPutative Gtpase Regulator +5

Cyclin-dependent kinases as a therapeutic target for stroke

Hitoshi Osuga, Sachiko Osuga, Fuhu Wang, +6

Proceedings of the National Academy of Sciences

Cell DeathCerebrovascular DiseaseGliomaCerebral Vascular RegulationThrombosis +18

Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance after Global Ischemia in the Rat

Fuhu Wang, Dale Corbett, Hitoshi Osuga, +6

Journal of Cerebral Blood Flow & Metabolism

ApoptosisCell DeathPharmacotherapyNeurotransmissionCellular Physiology +22

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

Asako Otomo, Ryota Kunita, Kyoko Suzuki-Utsunomiya, +5

Biochemical and Biophysical Research Communications

Als2/alsin DeficiencyAmyotrophic Lateral SclerosisAxonal GrowthDegenerative DiseaseNeuroscience +6

A Dopamine D4 Receptor Antagonist Attenuates Ischemia-Induced Neuronal Cell Damage via Upregulation of Neuronal Apoptosis Inhibitory Protein

Yoshinori Okada, Harumi Sakai, Eri Kohiki, +6

Journal of Cerebral Blood Flow & Metabolism

Apoptosis ProteinApoptosisImmunologyCell DeathPharmacotherapy +14

Identification and Characterization of the Miniature Pig Huntington's Disease Gene Homolog: Evidence for Conservation and Polymorphism in the CAG Triplet Repeat

Noriko Matsuyama, Shinji Hadano, Kyuichiro Onoe, +4

Genomics

BiologyGenetic DisorderGeneticsCag Triplet RepeatGenetic Epidemiology +7

Neuronal apoptosis inhibitory protein (NAIP) may enhance the survival of granulosa cells thus indirectly affecting oocyte survival

Taisuke Nakayama, Harumi Sakai, Kentaro Tanemura, +3

Molecular Reproduction and Development

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics

Kyoko Suzuki-Utsunomiya, Shinji Hadano, Asako Otomo, +4

Biochemical and Biophysical Research Communications

Amyotrophic Lateral SclerosisEndocytic PathwayAls2-mediated Endosome DynamicsIntracellular TraffickingCellular Biochemistry +3

Relevance of Interstitial Glutamate to Selective Vulnerability in Focal Cerebral Ischemia

Hitoshi Osuga, Antoine M. Hakim

Journal of Cerebral Blood Flow & Metabolism

Relationship between Extracellular Glutamate Concentration and Voltage-Sensitive Calcium Channel Function in Focal Cerebral Ischemia in the Rat

Hitoshi Osuga, Antoine M. Hakim

Journal of Cerebral Blood Flow & Metabolism