Asako Otomo

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Collette K. Hand, Hitoshi Osuga, Yoshiko Yanagisawa et al. · Nature Genetics · 2001 · 676 citations

Life Sciences, Genetics, Neuroscience +14

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

Asako Otomo · Human Molecular Genetics · 2003 · 246 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

Shinji Hadano, Susanna C. Benn, Shigeru Kakuta et al. · Human Molecular Genetics · 2005 · 136 citations

Life Sciences, Neurobiology, Neuroscience +17

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

Ryota Kunita, Asako Otomo, Hikaru Mizumura et al. · Journal of Biological Chemistry · 2007 · 89 citations · Full text

Life Sciences, Cell Biology, Neuroscience +17

Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking

Ryota Kunita, Asako Otomo, Hikaru Mizumura et al. · Journal of Biological Chemistry · 2004 · 69 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15