Asako Otomo

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Collette K. Hand, Hitoshi Osuga, Yoshiko Yanagisawa et al. · Nature Genetics · 2001 · 675 citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Genetics +7

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

Asako Otomo · Human Molecular Genetics · 2003 · 246 citations · Full text

Molecular Biology, Endocytic Pathway, Cell Signaling +16

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

Shinji Hadano, Susanna C. Benn, Shigeru Kakuta et al. · Human Molecular Genetics · 2005 · 136 citations

Rab5 Guanine, Endosome Trafficking, Als2 Gene +16

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

Ryota Kunita, Asako Otomo, Hikaru Mizumura et al. · Journal of Biological Chemistry · 2007 · 89 citations · Full text

Als2 Gene Cause, Amyotrophic Lateral Sclerosis, Signal Transduction +15

Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking

Ryota Kunita, Asako Otomo, Hikaru Mizumura et al. · Journal of Biological Chemistry · 2004 · 68 citations · Full text