Asako Otomo - Concepedia

Author

Asako Otomo

Tokai University ORCID

Also Known As

A OTOMO, A Otomo, A. Otomo, Asako OTOMO, Asako Otomo, Asako Otomo (251531), Otomo, Asako

Publications

2.7K

Citations

H-Index

Concepts

All Affiliations

Tokai University University of Ottawa Japan Science and Technology Agency West China Hospital of Sichuan University Sichuan University

About

Asako Otomo is an author at Tokai University specializing in medicine, cell biology, and genetics.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	12	12	1.4K
2	Natural Sciences	4	4	318
3	Biology	2	2	51
4	Public Health	1	1	20
5	Social Sciences	1	1	136

Asako Otomo

Publications

1.8K

Citations

H-Index

Page 1

	Year	Citations
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 Collette K. Hand, Hitoshi Osuga, Yoshiko Yanagisawa, Nature Genetics Neurodegenerative DiseasesAmyotrophic Lateral SclerosisGeneticsExperimental NeuropathologyPutative Gtpase Regulator	2001	675
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics Asako Otomo Human Molecular Genetics Molecular BiologyEndocytic PathwayCell SignalingMotor Neuron DiseasesExchange Factor	2003	246
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking Shinji Hadano, Susanna C. Benn, Shigeru Kakuta, Human Molecular Genetics Rab5 GuanineEndosome TraffickingAls2 GeneSocial SciencesNeurology	2005	136
The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis Ryota Kunita, Asako Otomo, Hikaru Mizumura, Journal of Biological Chemistry Als2 Gene CauseAmyotrophic Lateral SclerosisSignal TransductionMotor NeuronsAutophagy	2007	89
Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking Ryota Kunita, Asako Otomo, Hikaru Mizumura, Journal of Biological Chemistry	2004	68
Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases Asako Otomo, Lei Pan, Shinji Hadano Neurology Research International	2012	63
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice Shinji Hadano, Shun Mitsui, Lei Pan, Human Molecular Genetics	2016	59
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation Asako Otomo, Ryota Kunita, Kyoko Suzuki-Utsunomiya, FEBS Letters	2011	48
ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth Asako Otomo, Ryota Kunita, Kyoko Suzuki-Utsunomiya, Biochemical and Biophysical Research Communications Als2/alsin DeficiencyAmyotrophic Lateral SclerosisAxonal GrowthDegenerative DiseaseNeuroscience	2008	42
ALS2CL, the novel protein highly homologous to the carboxy‐terminal half of ALS2, binds to Rab5 and modulates endosome dynamics Shinji Hadano, Asako Otomo, Kyoko Suzuki-Utsunomiya, FEBS Letters	2004	41

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