Greg J. Reinhart

Crystal Structure of a Lipid G Protein–Coupled Receptor

Michael A. Hanson, C. Roth, Euijung Jo et al. · Science · 2012 · 668 citations

Life Sciences, Biochemistry, Pharmacology +17

Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7

Trudy A. Kohout, Shelby Nicholas, Stephen J. Perry et al. · Journal of Biological Chemistry · 2004 · 328 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Discovery of Sodium <i>R</i>-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Chen Chen, Dongpei Wu, Zhiqiang Guo et al. · Journal of Medicinal Chemistry · 2008 · 119 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

3-[(2<i>R</i>)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a Potent and Orally Active Antagonist of the Human Gonadotropin-Releasing Hormone Receptor. Design, Synthesis, and in Vitro and in Vivo Characterization

Fábio C. Tucci, Yunfei Zhu, R. Scott Struthers et al. · Journal of Medicinal Chemistry · 2005 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

Zhiqiang Guo, Yunfei Zhu, Timothy D. Gross et al. · Journal of Medicinal Chemistry · 2004 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17