Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice

Changtao Jiang, Aijuan Qu, Tsutomu Matsubara, +5

Diabetes

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

Matthew J. Taylor, Aijuan Qu, Erik R. Anderson, +4

Gastroenterology

Iron DeficiencyNutritionInflammationHypoxia-inducible Factor-2α MediatesNutrient Bioavailability +13

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

Aijuan Qu, Matthew J. Taylor, Xiang Xue, +5

Hepatology

FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice

Xuebo Pan, Yihui Shao, Fan Wu, +16

Cell Metabolism

HypertensionCardiovascular DiseaseMedicineAntihypertensive TherapyPhysiology +7

Hypoxia-Inducible Factor-2α Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis

Xiang Xue, Matthew J. Taylor, Erik R. Anderson, +6

Cancer Research

Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis

Jiangying Kuang, Yuwei Zhang, Qinhui Liu, +15

Diabetes

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Tingting Yan, Yuhong Luo, Nana Yan, +20

Hepatology

YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice

Shicheng Fan, Yue Gao, Aijuan Qu, +12

Hepatology

Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells

Chad Brocker, Jiang Yue, Donghwan Kim, +3

American Journal of Physiology-Gastrointestinal and Liver Physiology

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism

Li Mo, Jing Shen, Qinhui Liu, +9

Molecular Endocrinology

Irisin Transgenic MiceSc AdipocytesIrisin IsInsulin SignalingGastrointestinal Peptide Hormone +17