U. Obst-Sander

Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HC_αCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles

Jacob Olsen, David W. Banner, Paul Seiler et al. · ChemBioChem · 2004 · 148 citations

Quantification of Cation–π Interactions in Protein–Ligand Complexes: Crystal‐Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand

K. Schärer, Martin Morgenthaler, Ralph Paulini et al. · Angewandte Chemie International Edition · 2005 · 104 citations

Engineering, Chemical Analysis, Theoretical Inorganic Chemistry +20

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pK_aand binding affinity and evidence for intermolecular C–F⋯CN interactions

Jacob Olsen, Paul Seiler, Björn Wagner et al. · Organic & Biomolecular Chemistry · 2004 · 95 citations

A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on p<i>K</i>_a and log <i>D</i> Values

Eliane Schweizer, Anja Hoffmann‐Röder, K. Schärer et al. · ChemMedChem · 2006 · 58 citations

Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib

U. Obst-Sander, Antônio Ricci, Bernd Kuhn et al. · Journal of Medicinal Chemistry · 2022 · 35 citations · Full text