Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31

Taro Ishiguro, Nozomu Sato, Morio Ueyama, +16

Neuron

Rna Chaperone Tdp-43Regulatory RoleNatural SciencesRna BiologyMolecular Biology +4

Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities

Eiichi Tokuda, Eriko Okawa, Shunsuke Watanabe, +2

Neurobiology of Disease

BiochemistryNatural SciencesMetalloproteinCopper-binding AbilitiesBioactive Metal +9

Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

Eiichi Tokuda, Yo-ichi Takei, Shinji Ohara, +3

Molecular Neurodegeneration

Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis

Eiichi Tokuda, Shin-ichi Ono, Kumiko Ishige, +3

Toxicology

Amyotrophic Lateral SclerosisZinc ConcentrationsBioactive MetalMetalloproteinPhysiology +7

Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase‐linked familial amyotrophic lateral sclerosis

Eiichi Tokuda, Eriko Okawa, Shin‐ichi Ono

Journal of Neurochemistry

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisBioactive MetalIntracellular CopperMetalloprotein +11

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

Eiichi Tokuda, Shin-ichi Ono, Kumiko Ishige, +4

Experimental Neurology

Ammonium Tetrathiomolybdate DelaysAmyotrophic Lateral SclerosisNeurochemical BiomarkersNeuroscienceNeurology +5

Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

Eiichi Tokuda, Eriko Okawa, Shunsuke Watanabe, +1

Human Molecular Genetics

Amyotrophic Lateral SclerosisBiochemistryNatural SciencesMetalloproteinBioactive Metal +11

Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase

Eiichi Tokuda, Thomas Brännström, Peter M. Andersen, +1

Acta Neuropathologica Communications

A misfolded dimer of Cu/Zn‐superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, +5

Protein Science

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Eiichi Tokuda, Takao Nomura, Shinji Ohara, +5

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Amyotrophic Lateral SclerosisBiochemistryMutant Cu/zn-superoxide DismutaseNatural SciencesCopper-deficient Form +8