Thomas Luebbers

Novel Inhibitors of DNA Gyrase:  3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

Hans-Joachim Boehm, Markus Boehringer, Daniel Bur et al. · Journal of Medicinal Chemistry · 2000 · 378 citations

Drug Target, Biochemistry, Hit Validation +15

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Manaswini Sivaramakrishnan, Kathleen McCarthy, Sébastien Campagne et al. · Nature Communications · 2017 · 219 citations · Full text

Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation

Richard Page, Karlheinz Baumann, Masanori Tomioka et al. · Journal of Biological Chemistry · 2007 · 160 citations · Full text

Molecular Biology, Aβ42 Is Independently, Alzheimer's Disease +20

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

Amelie Ebke, Thomas Luebbers, Akio Fukumori et al. · Journal of Biological Chemistry · 2011 · 85 citations · Full text

Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase

Edith Winkler, Scott Hobson, Akio Fukumori et al. · Biochemistry · 2009 · 69 citations