Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)

Thomas Müller‐Späth, Lars Aumann, Lena Melter, +2

Biotechnology and Bioengineering

EngineeringSolvent GradientsImmunologyChromatographic SeparationPreparative Application +18

A continuous, counter-current multi-column chromatographic process incorporating modifier gradients for ternary separations

Guido Ströhlein, Lars Aumann, Marco Mazzotti, +1

Journal of Chromatography A

Ternary SeparationsBiochemistrySeparation ScienceNatural SciencesGas Chromatography +10

Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP)

Thomas Müller‐Späth, Martin Krättli, Lars Aumann, +2

Biotechnology and Bioengineering

Immunocytochemical TechniqueEngineeringImmunologyMcsgp ProcessImmunotherapy +17

Two step capture and purification of IgG₂ using multicolumn countercurrent solvent gradient purification (MCSGP)

Thomas Müller‐Späth, Lars Aumann, Guido Ströhlein, +9

Biotechnology and Bioengineering

Solvent ExtractionEngineeringStep CaptureCell CulturePreparative Application +22

Optimizing model predictive control of the chromatographic multi-column solvent gradient purification (MCSGP) process

Cristian Grossmann, Guido Ströhlein, Manfred Morari, +1

Journal of Process Control

Purification MethodEngineeringSeparation ScienceProcess ControlDownstream Processing +6

Model simulation and experimental verification of a cation-exchange IgG capture step in batch and continuous chromatography

Thomas Müller‐Späth, Guido Ströhlein, Lars Aumann, +9

Journal of Chromatography A

Experimental VerificationEngineeringChemistrySeparation ScienceGas Chromatography +14

Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography

Bertrand Guélat, Guido Ströhlein, Marco Lattuada, +3

Journal of Chromatography A

Simulation ModelImmunohematologyIon-exchange ChromatographyEngineeringBioanalysis +10

Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A

Bertrand Guélat, Guido Ströhlein, Marco Lattuada, +1

Journal of Chromatography A

Protein ChemistryEngineeringIon ExchangeBiochemistryBioanalysis +9

Esterification of acrylic acid with methanol by reactive chromatography: Experiments and simulations

Guido Ströhlein, Yolanda Assunção, Nikhil Dube, +3

Chemical Engineering Science

Chemical EngineeringEngineeringNatural PolymerAcrylic AcidMethanol +6

Hybrid Processes: Design Method for Optimal Coupling of Chromatography and Crystallization Units

Guido Ströhlein, Michael Schulte, Jochen Strube

Separation Science and Technology

EngineeringChemical Engineering SeparationsPreparative ApplicationChemistrySeparation Science +16