Matthew T. MacDonough

Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)

Matthew T. MacDonough, Tracy E. Strecker, Ernest Hamel et al. · Bioorganic & Medicinal Chemistry · 2013 · 73 citations · Full text

Anti-cancer Agents, Medicinal Chemistry, Medicine +11

Synthesis of a 2-Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent

Mallinath B. Hadimani, Matthew T. MacDonough, Anjan Ghatak et al. · Journal of Natural Products · 2013 · 59 citations · Full text

Bioorganic Chemistry, Chemoprevention Strategy, 2-Aryl-3-aroyl Indole Salt +20

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

G.D. Kishore Kumar, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 43 citations · Full text

Medicinal Chemistry, Cathepsin L Inhibitors, Biochemistry +11

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents

Rajendra P. Tanpure, Clinton S. George, Tracy E. Strecker et al. · Bioorganic & Medicinal Chemistry · 2013 · 38 citations · Full text

Anti-cancer Agents, Engineering, Medicine +8

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts

Tracy E. Strecker, Samuel O. Odutola, Ramona Lopez et al. · Cancer Letters · 2015 · 33 citations · Full text

Angiogenesis, Endothelial Cells, Biochemistry +14