Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis

Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, +21

Nature Cell Biology

InflammationSystems BiologySclerostinAutoimmune DiseaseBone Morphogenic Protein +13

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

Hyota Takamatsu, Noriko Takegahara, Yukinobu Nakagawa, +16

Nature Immunology

Signal TransductionMolecular PhysiologyCell TraffickingImmunologyLymphatic System +12

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

Tomohiro Koga, Christian M. Hedrich, Masayuki Mizui, +6

Journal of Clinical Investigation

Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice

Atsushi Kumanogoh, Takashi Shikina, Kazuhiro Suzuki, +19

Immunity

Autoimmune DiseaseAdaptive Immune SystemT-regulatory CellImmune RegulationImmunology +8

The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

Eri Katsuyama, Abel Suárez‐Fueyo, Sean J. Bradley, +9

Cell Reports

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8− IL-17–Producing T Cells

Masayuki Mizui, Tomohiro Koga, Linda A. Lieberman, +5

The Journal of Immunology

Multiple End-organ DamageT-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +18

The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients

Katsue Sunahori, Kamalpreet Nagpal, Christian M. Hedrich, +3

Journal of Biological Chemistry

B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

Mike Recher, Siobhan O. Burns, Miguel Á. de la Fuente, +32

Blood

Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Lupus

Tomohiro Koga, Kunihiro Ichinose, Masayuki Mizui, +2

The Journal of Immunology

Exploring RNA interference as a therapeutic strategy for renal disease

Y. Takabatake, Yoshitaka Isaka, Masayuki Mizui, +5

Gene Therapy

UrologyMedicineMolecular BiologyTherapeutic StrategyGenome Editing +6