Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

Ayinuer Adijiang, Shunsuke Goto, S. Uramoto, +2

Nephrology Dialysis Transplantation

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

Yun‐Hee Youm, Ayinuer Adijiang, Bolormaa Vandanmagsar, +3

Endocrinology

ImmunologyImmune RegulationPathologyCell DeathInsulin Signaling +20

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

Yun‐Hee Youm, Thirumala‐Devi Kanneganti, Bolormaa Vandanmagsar, +8

Cell Reports

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

Hidehisa Shimizu, Dilinaer Bolati, Ayinuer Adijiang, +5

American Journal of Physiology-Cell Physiology

ImmunologyRenal InflammationPathologyCell ProliferationCellular Physiology +19

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate

Hidehisa Shimizu, Dilinaer Bolati, Ayinuer Adijiang, +4

American Journal of Physiology-Cell Physiology

AgingApoptosisRenal PathologyRenal InflammationPathology +23

Indoxyl Sulfate Downregulates Renal Expression of Klotho through Production of ROS and Activation of Nuclear Factor-ĸB

Hidehisa Shimizu, Dilinaer Bolati, Ayinuer Adijiang, +7

American Journal of Nephrology

Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats

Ayinuer Adijiang, Yusuke Higuchi, Fuyuhiko Nishijima, +2

Biochemical and Biophysical Research Communications

InflammationHypertensionIndoxyl SulfateAgingMedicine +13

Indoxyl Sulfate Reduces Klotho Expression and Promotes Senescence in the Kidneys of Hypertensive Rats

Ayinuer Adijiang, Hidehisa Shimizu, Yusuke Higuchi, +2

Journal of Renal Nutrition

HypertensionMedicineVascular PharmacologyPhysiologyPharmacology +7

Pyridoxal phosphate prevents progression of diabetic nephropathy

Sho Nakamura, H. Li, Ayinuer Adijiang, +2

Nephrology Dialysis Transplantation

Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Adekunle Alabi, Xiaodan Xia, Hongmei Gu, +11

Nature Communications