Concepedia

Karolina Madela

KM

Statistics

Publications

8

Citations

417

H-Index

8

Active since

2009

Affiliations

Cardiff University(Current)

Senex Biotechnology (United States)

Rega Institute for Medical Research

CiVentiChem (United States)

KU Leuven

Karolina Madela is an author at Cardiff University specializing in medicinal chemistry, pharmacology, and pharmacy.

Publications per year

2009–2013

8

Publications

8

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus

Christopher McGuigan, Karolina Madela, Mohamed Aljarah et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 99 citations

, , +9

INX-08189, a Phosphoramidate Prodrug of 6-<i>O</i>-Methyl-2′-<i>C</i>-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties

John Vernachio, Blair Bleiman, K. Dawn Bryant et al. · Antimicrobial Agents and Chemotherapy · 2011 · 84 citations · Full text

, , +17

Phosphoramidate ProTides of 2′-<i>C</i>-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties

Christopher McGuigan, Arnaud Gilles, Karolina Madela et al. · Journal of Medicinal Chemistry · 2010 · 56 citations

, , +14

Phosphorodiamidates as a Promising New Phosphate Prodrug Motif for Antiviral Drug Discovery: Application to Anti-HCV Agents

Christopher McGuigan, Karolina Madela, Mohamed Aljarah et al. · Journal of Medicinal Chemistry · 2011 · 54 citations

, , +16

The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

Christopher McGuigan, Plinio Perrone, Karolina Madela et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 42 citations

, , +8

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