Jakob S. Pallesen

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

Jakob S. Pallesen, Kim T. Tran, Anders Bach · Journal of Medicinal Chemistry · 2018 · 110 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

Kim T. Tran, Jakob S. Pallesen, Sara M. Ø. Solbak et al. · Journal of Medicinal Chemistry · 2019 · 99 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Jakob S. Pallesen, Dilip Narayanan, Kim T. Tran et al. · Journal of Medicinal Chemistry · 2021 · 56 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery

Dilip Narayanan, Kim T. Tran, Jakob S. Pallesen et al. · Journal of Medicinal Chemistry · 2022 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

<i>N</i>1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure–Affinity Relationships, and in Vitro Pharmacology

Jakob S. Pallesen, Stine Møllerud, Karla Frydenvang et al. · ACS Chemical Neuroscience · 2019 · 13 citations

Medicine, Medicinal Chemistry, Pharmacology +17