A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

Jalal Taneera, Stefan Lang, Amitabh Sharma, +19

Cell Metabolism

TCF7L2 is a master regulator of insulin production and processing

Yuedan Zhou, Soo Young Park, Jing Su, +17

Human Molecular Genetics

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

Taman Mahdi, Sonja Hänzelmann, Albert Salehi, +20

Cell Metabolism

Metabolic SyndromeProtein SecretionMolecular PhysiologySignal TransductionEngineering +12

A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia

Dimitris A. Papanicolaou, Shabana Ather, Hao Zhu, +4

The journal of nutrition health & aging

Hormonal ContraceptiveFemale ParticipantsMedicineAnabolic SteroidsPlacebo-controlled Clinical Trial +9

Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes

George Hindy, Emily Sonestedt, Ulrika Ericson, +6

Diabetologia

Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway

Yuedan Zhou, Enming Zhang, Christine Berggreen, +8

Human Molecular Genetics

ApoptosisImmunologyCell DeathInsulin SignalingSignaling Pathway +15

N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

Kristoffer Ström, David Morales‐Álamo, Filip Ottosson, +23

Scientific Reports

Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes

Johanna Säll, Annie M. L. Pettersson, Christel Björk, +11

Diabetologia

Genome-wide association studies uncover genes associated with litter traits in the pig

Yunxiang Zhao, Guangxiong Gao, Yuedan Zhou, +4

animal

GeneticsGenomicsTotal NumberAnimal GeneticsGenomic Prediction +17

First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle

Targ Elgzyri, Hemang Parikh, Yuedan Zhou, +9

The Journal of Clinical Endocrinology & Metabolism