Valerie Askew

Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3<i>R</i>,5<i>R</i>)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2<i>H</i>-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia

Jeffrey A. Pfefferkorn, Chulho Choi, Scott D. Larsen et al. · Journal of Medicinal Chemistry · 2007 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

William K.C. Park, Robert M. Kennedy, Scott D. Larsen et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn, Yuntao Song, Kuai-Lin Sun et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn, Chulho Choi, Yuntao Song et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

Jeffrey A. Pfefferkorn, John Litchfield, R. H. Hutchings et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8