Kathleen Chen

Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk

Jian Zhou, Chandra L. Theesfeld, Kevin Yao et al. · Nature Genetics · 2018 · 575 citations · Full text

Variant Effects, Genome-wide Association Study, Engineering +7

A sequence-based global map of regulatory activity for deciphering human genetics

Kathleen Chen, Aaron K. Wong, Olga G. Troyanskaya et al. · Nature Genetics · 2022 · 252 citations · Full text

Genomic analyses implicate noncoding de novo variants in congenital heart disease

Felix Richter, Sarah U. Morton, Seong Won Kim et al. · Nature Genetics · 2020 · 167 citations · Full text

Variant Interpretation, Genetics, Congenital Heart Defect +7

Selene: a PyTorch-based deep learning library for sequence data

Kathleen Chen, Evan M. Cofer, Jian Zhou et al. · Nature Methods · 2019 · 141 citations · Full text

Natural Language Processing, Structured Prediction, Sequence Modelling +8

Unsupervised Extraction of Stable Expression Signatures from Public Compendia with an Ensemble of Neural Networks

Jie Tan, Georgia Doing, Kimberley A. Lewis et al. · Cell Systems · 2017 · 100 citations · Full text

Artificial Intelligence, Cross-experiment Comparisons, Machine Learning +26