Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

Axel Bouchon, Jes Dietrich, Marco Colonna

The Journal of Immunology

TREM-1 amplifies inflammation and is a crucial mediator of septic shock

Axel Bouchon, Fabio Facchetti, Markus A. Weigand, +1

Nature

InflammationCytokineTrem-1 Amplifies InflammationInnate Immune SystemImmunology +9

A Dap12-Mediated Pathway Regulates Expression of Cc Chemokine Receptor 7 and Maturation of Human Dendritic Cells

Axel Bouchon, Cristina Hernández-Munaín, Marina Cella, +1

The Journal of Experimental Medicine

TREM-1–expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases

Mirjam Schenk, Axel Bouchon, Frank Seibold, +1

Journal of Clinical Investigation

Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells.

Henning Walczak, Axel Bouchon, Heiko Stahl, +1

PubMed

MitophagyApoptosisImmunologyCell DeathPathology +17

Cutting Edge: Activation of NK Cell-Mediated Cytotoxicity by a SAP-Independent Receptor of the CD2 Family

Axel Bouchon, Marina Cella, Helen L. Grierson, +2

The Journal of Immunology

Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity

Hideo Nakajima, Marina Cella, Axel Bouchon, +5

European Journal of Immunology

ImmunologyImmune RegulationCell DeathPathologyImmunologic Mechanism +15

Macrophages Expressing Triggering Receptor Expressed on Myeloid Cells-1 Are Underrepresented in the Human Intestine

Mirjam Schenk, Axel Bouchon, Stefan Birrer, +2

The Journal of Immunology

Immune RegulationImmunologyCell DeathPathologyImmune System +17

Critical role for mitochondria in B cell receptor‐mediated apoptosis

Axel Bouchon, Peter H. Krammer, Henning Walczak

European Journal of Immunology

Mitochondrial FunctionMedicineApoptosisImmunologyCell Death +12

Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation

Christian Bopp, Stefan Hofer, Axel Bouchon, +3

European Journal of Anaesthesiology