Vicky Howe

New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE , two key control enzymes in cholesterol synthesis

Vicky Howe, Laura J. Sharpe, Anika V. Prabhu et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2017 · 83 citations

Oxysterol, Biochemistry, Cellular Cholesterol Acquisition +10

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

Ngee Kiat Chua, Vicky Howe, Nidhi Jatana et al. · Journal of Biological Chemistry · 2017 · 66 citations · Full text

The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters

Shereen M. Aleidi, Vicky Howe, Laura J. Sharpe et al. · Journal of Biological Chemistry · 2015 · 51 citations · Full text

Molecular Regulation, Molecular Biology, Autophagy +17

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

Vicky Howe, Ngee Kiat Chua, Julian Stevenson et al. · Journal of Biological Chemistry · 2015 · 49 citations · Full text

Regulatory Domain, Oxysterol, Biochemistry +7

Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation

Laura J. Sharpe, Vicky Howe, Nicola A. Scott et al. · Journal of Biological Chemistry · 2018 · 46 citations · Full text