Laura J. Sharpe

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

Noam Zelcer, Laura J. Sharpe, Anke Loregger et al. · Molecular and Cellular Biology · 2014 · 171 citations · Full text

Lipid Peroxidation, Molecular Biology, Redox Biology +16

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

Anika V. Prabhu, Winnie Luu, Laura J. Sharpe et al. · Journal of Biological Chemistry · 2016 · 147 citations · Full text

New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE , two key control enzymes in cholesterol synthesis

Vicky Howe, Laura J. Sharpe, Anika V. Prabhu et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2017 · 83 citations

Oxysterol, Biochemistry, Cellular Cholesterol Acquisition +10

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

Winnie Luu, Gene Hart‐Smith, Laura J. Sharpe et al. · Journal of Lipid Research · 2015 · 82 citations · Full text

Akt acutely activates the cholesterogenic transcription factor SREBP-2

Winnie Luu, Laura J. Sharpe, Julian Stevenson et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2011 · 71 citations

Transcriptional Regulation, Signal Transduction, Molecular Physiology +7