Concepedia

Ngee Kiat Chua

NK

11

Publications

580

Citations

11

H-Index

2015

Active since

Affiliations

UNSW Sydney(Current)

The University of Melbourne

Walter and Eliza Hall Institute of Medical Research

Ngee Kiat Chua is an author at UNSW Sydney specializing in biochemistry, medicine, and molecular biology.

ORCID

Top concepts

Publications per year

2015–2023

11

Publications

11

Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis

Soo Young Jun, Andrew J. Brown, Ngee Kiat Chua et al. · Gastroenterology · 2020 · 181 citations

, , +7

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

H. YOSHIOKA, Hudson W. Coates, Ngee Kiat Chua et al. · Proceedings of the National Academy of Sciences · 2020 · 82 citations · Full text

, , +16

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

Ngee Kiat Chua, Vicky Howe, Nidhi Jatana et al. · Journal of Biological Chemistry · 2017 · 66 citations · Full text

Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and <scp>IL</scp> ‐1β release in X‐linked inhibitor of apoptosis ( <scp>XIAP</scp> ) deficiency

Sebastian Hughes, Meng Lin, Ashley Weir et al. · The EMBO Journal · 2023 · 55 citations · Full text

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

Vicky Howe, Ngee Kiat Chua, Julian Stevenson et al. · Journal of Biological Chemistry · 2015 · 49 citations · Full text

, , +7

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