Environmental Conditions Affect the Kinetics of Nucleation of Amyloid Fibrils and Determine Their Morphology

Bertrand Morel, Lorena Varela, Ana I. Azuaga, +1

Biophysical Journal

Biophysical ModelingAlzheimer's DiseaseBiochemistryDetermine Their MorphologyProtein Folding +7

The Thermodynamic Stability of Amyloid Fibrils Studied by Differential Scanning Calorimetry

Bertrand Morel, Lorena Varela, Francisco Conejero‐Lara

The Journal of Physical Chemistry B

Characterization of Oligomers of Heterogeneous Size as Precursors of Amyloid Fibril Nucleation of an SH3 Domain: An Experimental Kinetics Study

David Ruzafa, Bertrand Morel, Lorena Varela, +2

PLoS ONE

Protein AssemblyAmyloid AggregationMolecular BiologyProtein Phase SeparationAnalytical Ultracentrifugation +16

Early Amyloidogenic Oligomerization Studied through Fluorescence Lifetime Correlation Spectroscopy

José M. Paredes, Salvador Casares, María J. Ruedas-Rama, +4

International Journal of Molecular Sciences

Persistent Biomedical ProblemSingle Molecule BiophysicsAlzheimer's DiseaseBiochemistryAmyloidogenic Protein Aggregation +12

A single mutation in an SH3 domain increases amyloid aggregation by accelerating nucleation, but not by destabilizing thermodynamically the native state

Lorena Varela, Bertrand Morel, Ana I. Azuaga, +1

FEBS Letters

A model for the aggregation of the acylphosphatase from Sulfolobus solfataricus in its native-like state

Francesco Bemporad, Tommaso Vannocci, Lorena Varela, +2

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

BiosynthesisBioorganic ChemistryBiochemistryNatural SciencesEnzyme Catalysis +4

A quantitative assay to study the lipid selectivity of membrane-associated systems using solution NMR

Encarnación Medina‐Carmona, Lorena Varela, Alex C. Hendry, +5

Chemical Communications

Biochemical Characterization of the Integrin Interactome

Rejina B. Khan, Lorena Varela, Alana R. Cowell, +1

Methods in molecular biology

Integrin InteractomeBiochemistryCell-matrix InteractionBiochemical InteractionBiomolecular Interaction +1

Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation

Alana R. Cowell, Guillaume Jacquemet, Abhimanyu K. Singh, +7

The Journal of Cell Biology

Molecular RegulationMolecular BiologyCytoskeletonTalin R7r8Cellular Physiology +19

Mapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis

David Ruzafa, Lorena Varela, Ana I. Azuaga, +2

Physical Chemistry Chemical Physics

Protein AssemblyAmyloid AggregationMolecular BiologyProtein Phase SeparationAmyloid Nucleation Precursors +15