Encarnación Medina‐Carmona

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

Encarnación Medina‐Carmona, Rogelio Palomino‐Morales, Julian E. Fuchs et al. · Scientific Reports · 2016 · 49 citations · Full text

Medicine, Molecular Biology, Oncology +14

Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses

Encarnación Medina‐Carmona, Isabel Betancor-Fernández, Jaime Santos et al. · Human Molecular Genetics · 2018 · 42 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

Encarnación Medina‐Carmona, José L. Neira, Eduardo Salido et al. · Scientific Reports · 2017 · 39 citations · Full text

Life Sciences, Molecular Biology, Oncology +13

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

Encarnación Medina‐Carmona, Julian E. Fuchs, Noel Mesa‐Torres et al. · Human Molecular Genetics · 2017 · 38 citations · Full text

Life Sciences, Biology, Molecular Biology +15

Second Generation of Mannich Base-Type Derivatives with <i>in Vivo</i> Activity against <i>Trypanosoma cruzi</i>

Rubén Martín‐Escolano, Elsa Moreno‐Viguri, Mery Santivañez‐Veliz et al. · Journal of Medicinal Chemistry · 2018 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14