A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

Megan M. Price, Carole A. Oskeritzian, Yves T. Falanga, +7

Journal of Allergy and Clinical Immunology

InflammationAsthmaSignal TransductionAllergyInflammatory Lung Disease +10

Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

Carole A. Oskeritzian, Megan M. Price, Nitai C. Hait, +6

The Journal of Experimental Medicine

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses

Carole A. Oskeritzian, Nitai C. Hait, Piper Wedman, +9

Journal of Allergy and Clinical Immunology

Inflammatory Lung DiseaseLung InflammationAxis RegulatesMast Cell DisorderImmune Regulation +14

IL-4 and TGF-β1 Counterbalance One Another while Regulating Mast Cell Homeostasis

Matthew Macey, Jamie Sturgill, Johanna K. Morales, +13

The Journal of Immunology

Mast Cell DisorderT-regulatory CellImmune RegulationImmunologyImmune System +16

Genotype-Dependent Effects of TGF-β1 on Mast Cell Function: Targeting the Stat5 Pathway

Josephine Fernando, Travis Faber, Yves T. Falanga, +11

The Journal of Immunology

Human GrowthMast Cell DisorderImmunologyImmune RegulationMast Cell Function +22

Novel Mechanism for FcϵRI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production

Brian Barnstein, Yves T. Falanga, Zhengqi Wang, +9

Journal of Biological Chemistry

The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling

Yves T. Falanga, Johanna K. Morales, John Ryan

Frontiers in Immunology

Mast Cell DisorderImmunologyImmune RegulationNew FrontierImmunologic Mechanism +28

Lyn but Not Fyn Kinase Controls IgG-Mediated Systemic Anaphylaxis

Yves T. Falanga, Natalia S. Chaimowitz, Nicolas Charles, +13

The Journal of Immunology

Clinical ImmunologyFyn Ko CellsMast Cell DisorderImmunologyImmune Regulation +16

High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells

Yves T. Falanga, Michela Frascoli, Yasin Kaymaz, +5

JCI Insight

Adaptive Immune SystemImmunodeficienciesT-regulatory CellImmunologyImmune Regulation +19

Fyn Kinase Is Required for Optimal Humoral Responses

Natalia S. Chaimowitz, Yves T. Falanga, John J. Ryan, +1

PLoS ONE

Immunological MemorySignal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunology +13