<i>ACVR1</i> ^<i>R206H</i> receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

Sarah Hatsell, Vincent Idone, Dana M. Alessi Wolken, +17

Science Translational Medicine

Activin FamilySclerostinCell DeathOsteogenesisOsteoporosis +17

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

Devaveena Dey, Jana Bagarova, Sarah Hatsell, +14

Science Translational Medicine

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

Carola Krause, Olexandr Korchynskyi, Karien E. de Rooij, +8

Journal of Biological Chemistry

SclerostinDistinct ModesImmunologyOsteoporosisBone Morphogenetic Protein +16

Gli3-mediated repression of Hedgehog targets is required for normal mammary development

Sarah Hatsell, Pamela Cowin

Development

GeneticsMammary Gland DevelopmentEmbryologyTissue DevelopmentSignaling Pathway +16

Conditionals by inversion provide a universal method for the generation of conditional alleles

Aris N. Economides, David Frendewey, Peter Yang, +31

Proceedings of the National Academy of Sciences

Reverse GeneticsGeneticsMolecular BiologyUniversal MethodGenomics +21

Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model

Cristal S. Yee, Liqin Xie, Sarah Hatsell, +5

Bone

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis

Jiun Chiun Chang, Aimy Sebastian, Deepa K. Murugesh, +3

Journal of Orthopaedic Research®

Tibial CompressionEngineeringGeneticsOrthopedic BiomechanicsOrthopaedic Surgery +20

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent

Jaymin Upadhyay, Liqin Xie, Lily Huang, +18

Journal of Bone and Mineral Research

MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors

Brigitte Teissedre, Alicia Pinderhughes, Angela Incassati, +3

PLoS ONE

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

Senem Aykul, Lily Huang, Lili Wang, +18

Journal of Clinical Investigation

SclerostinImmunologyPathologyCytoskeletonOrthopaedic Surgery +20