Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

Stephen Pasternak, Richard D. Bagshaw, Marianne Guiral, +5

Journal of Biological Chemistry

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Paul Markus Müller, Juliane Rademacher, Richard D. Bagshaw, +30

Nature Cell Biology

Systems AnalysisSignal TransductionEngineeringSignaling PathwayCell Adhesion +9

Identification of the Gene Encoding the Enzyme Deficient in Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C)

Xiaolian Fan, Huiwen Zhang, Sunqu Zhang, +4

The American Journal of Human Genetics

Enzyme DeficientPathogenesisPathologyMolecular GeneticsMicrobiology +4

Impaired Elastic-Fiber Assembly by Fibroblasts from Patients with Either Morquio B Disease or Infantile GM1-Gangliosidosis Is Linked to Deficiency in the 67-kD Spliced Variant of β-Galactosidase

Aleksander Hinek, Sunqu Zhang, Adam C. Smith, +1

The American Journal of Human Genetics

Connective Tissue DiseaseGlycobiologyPathology67-Kd Spliced VariantImpaired Elastic-fiber Assembly +5

Early-infantile galactosialidosis: Prenatal presentation and postnatal follow-up

Millan S. Patel, John W. Callahan, Sunqu Zhang, +10

American Journal of Medical Genetics

Identification of Glu-268 as the Catalytic Nucleophile of Human Lysosomal β-Galactosidase Precursor by Mass Spectrometry

John D. McCarter, David L. Burgoyne, Shichang Miao, +3

Journal of Biological Chemistry

Characterization of β-galactosidase mutations Asp332→Asn and Arg148→Ser, and a polymorphism, Ser532→Gly, in a case of GM1 gangliosidosis

Sunqu Zhang, Richard D. Bagshaw, William HILSON, +5

Biochemical Journal

Asn MutationGeneticsGlycobiologyImmunologyPathology +16

Early proteolytic cleavage with loss of a C-terminal fragment underlies altered processing of the <i>β</i>-galactosidase precursor in galactosialidosis

Yuko Okamura-Oho, Sunqu Zhang, William HILSON, +2

Biochemical Journal

C-terminal Fragment UnderliesGlycobiologyMolecular BiologyCell CultureCellular Physiology +17

Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease

Richard D. Bagshaw, Sunqu Zhang, Alina Hinek, +4

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Allelic VariantMendelian DisorderGenetic DisorderGeneticsPathogenesis +10

Maturation and degradation of β‐galactosidase in the post‐Golgi compartment are regulated by cathepsin B and a non‐cysteine protease

Yuko Okamura-Oho, Sunqu Zhang, John W. Callahan, +3

FEBS Letters