Christopher M. Incles

Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors

R. John Harrison, Javier Cuesta, Gianni Chessari et al. · Journal of Medicinal Chemistry · 2003 · 182 citations · Full text

Bioorganic Chemistry, Telomerase Activity, Molecular Biology +19

A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells

Christopher M. Incles, Christoph Schultes, Helena Kempski et al. · Molecular Cancer Therapeutics · 2004 · 156 citations · Full text

Genome Instability, Telomerase-telomere Capping Complex, Telomere Uncapping +14

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding

R. John Harrison, Anthony P. Reszka, Shozeb Haider et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 78 citations · Full text

Disubstituted Acridone Derivatives, Medicinal Chemistry, Bioorganic Chemistry +8

Acquired Cellular Resistance to Flavopiridol in a Human Colon Carcinoma Cell Line Involves Up-Regulation of the Telomerase Catalytic Subunit and Telomere Elongation. Sensitivity of Resistant Cells to Combination Treatment with a Telomerase Inhibitor

Christopher M. Incles, Christoph Schultes, Lloyd R. Kèlland et al. · Molecular Pharmacology · 2003 · 36 citations

Telomerase inhibitors in cancer therapy: current status and future directions.

Christopher M. Incles, Christoph Schultes, Stephen Neidle · PubMed · 2003 · 33 citations

Pathology, Molecular Biology, Anti-cancer Agent +17