Dimitar B. Gotchev

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 655 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9<i>R</i>)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Xiaotao Chen, Philip Pitis, Guodong Liu et al. · Journal of Medicinal Chemistry · 2013 · 203 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Spongipyran synthetic studies. Evolution of a scalable total synthesis of (+)-spongistatin 1

Amos B. Smith, Chris Sfouggatakis, Christina A. Risatti et al. · Tetrahedron · 2009 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Drug Discovery +7

Spongistatin Synthetic Studies. Evolution of a Scalable Synthesis for the EF Fragment of (+)-Spongistatin 1 Exploiting a Petasis−Ferrier Union/Rearrangement Tactic

Amos B. Smith, Chris Sfouggatakis, Dimitar B. Gotchev et al. · Organic Letters · 2004 · 40 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Synthetic Studies Toward (−)-FR901483 Using a Conjugate Allylation To Install the C-1 Quaternary Carbon

Dimitar B. Gotchev, Daniel L. Comins · The Journal of Organic Chemistry · 2006 · 39 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +10