Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

Matthew J. Winton, Lionel M. Igaz, Margaret Wong, +3

Journal of Biological Chemistry

Molecular BiologyDegenerative PathologyGenome InstabilityAggregate FormationNormal Nuclear Tdp-43 +14

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

Lionel M. Igaz, Linda K. Kwong, Edward B. Lee, +8

Journal of Clinical Investigation

Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system

Catherine Dubreuil, Matthew J. Winton, Lisa McKerracher

The Journal of Cell Biology

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

Lionel M. Igaz, Linda K. Kwong, Alice Chen‐Plotkin, +6

Journal of Biological Chemistry

Protein FunctionSignal TransductionAls BrainProtein ExpressionAmyotrophic Lateral Sclerosis +13

TDP-43 Mediates Degeneration in a Novel<i>Drosophila</i>Model of Disease Caused by Mutations in VCP/p97

Gillian P. Ritson, Sara K. Custer, Brian D. Freibaum, +10

Journal of Neuroscience

Pathological TDP-43 in parkinsonism–dementia complex and amyotrophic lateral sclerosis of Guam

Felix Geser, Matthew J. Winton, Linda K. Kwong, +8

Acta Neuropathologica

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisNeurobiology Of DiseasePathological Tdp-43Parkinson Disease +11

Application of Rho Antagonist to Neuronal Cell Bodies Promotes Neurite Growth in Compartmented Cultures and Regeneration of Retinal Ganglion Cell Axons in the Optic Nerve of Adult Rats

Johanne Bertrand, Matthew J. Winton, Nieves Rodriguez-Hernandez, +2

Journal of Neuroscience

Characterization of New Cell Permeable C3-like Proteins That Inactivate Rho and Stimulate Neurite Outgrowth on Inhibitory Substrates

Matthew J. Winton, Catherine Dubreuil, Dana D. Lasko, +2

Journal of Biological Chemistry

Protein SecretionGel Shift AssaysCytoskeletonCell GrowthCellular Physiology +16

A90V TDP‐43 variant results in the aberrant localization of TDP‐43 in vitro

Matthew J. Winton, Vivianna M. Van Deerlin, Linda K. Kwong, +10

FEBS Letters

Tardbp VariantAmyotrophic Lateral SclerosisMedicineGeneticsAberrant Localization +6

Rapid and Intermittent Cotransport of Slow Component-b Proteins

Subhojit Roy, Matthew J. Winton, Mark M. Black, +2

Journal of Neuroscience

Protein SecretionMolecular BiologyCytoskeletonCellular NeurobiologyCellular Physiology +15