Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Rob J.W. Arts, Boris Novakovic, Rob ter Horst, +26

Cell Metabolism

Autoimmune DiseaseAllergyTrained ImmunityImmunologyAutoimmunity +7

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J.W. Arts, Agostinho Carvalho, Claudia La Rocca, +13

Cell Reports

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Shih‐Chin Cheng, Brendon P. Scicluna, Rob J.W. Arts, +17

Nature Immunology

InflammationEnergy MetabolismGranulocyteImmunologyHematology +9

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

Ekta Lachmandas, Lily Boutens, Jacqueline M. Ratter, +9

Nature Microbiology

InflammationToll-like ReceptorsDifferent Toll-like ReceptorDysbiosisHost-microbe Interactions +11

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against <i>Mycobacterium tuberculosis</i> in human and murine cells

Ekta Lachmandas, Macarena Beigier‐Bompadre, Shih‐Chin Cheng, +15

European Journal of Immunology

Immune RegulationImmunologyMetabolic RemodelingImmune SystemHost Response +20

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein

Samuel T. Keating, Laszlo Groh, Kathrin Thiem, +20

Journal of Molecular Medicine

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

Ekta Lachmandas, Clare Eckold, Julia Böhme, +16

The Journal of Infectious Diseases

Diabetes Mellitus and Increased Tuberculosis Susceptibility: The Role of Short-Chain Fatty Acids

Ekta Lachmandas, Corina N. A. M. van den Heuvel, Michelle S. M. A. Damen, +3

Journal of Diabetes Research

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

Jorge Domínguez‐Andrés, Rob J.W. Arts, Rob ter Horst, +10

PLoS Pathogens

Microbial PathogensFungal Cell BiologyImmunologyCandida YeastClinical Mycology +17

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Julia Böhme, Núria Martínez, Shamin Li, +18

Nature Communications