Olena Barbash

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer et al. · Nature Chemical Biology · 2015 · 533 citations

Vitro Potency, Signal Transduction, Medicine +10

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Paweł K. Mazur, Nicolas Reynoird, Purvesh Khatri et al. · Nature · 2014 · 405 citations · Full text

Lysine Methylation, Medicine, Cancer Genomics +5

Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

Douglas I. Lin, Olena Barbash, Suresh Kumar et al. · Molecular Cell · 2006 · 341 citations · Full text

Protein Function, Signal Transduction, Biochemistry +10

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

Andrew Fedoriw, Satyajit Rajapurkar, Shane W. O’Brien et al. · Cancer Cell · 2019 · 333 citations · Full text

Cancer Research, Mtap Loss, Medicine +10

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

Jia Yi Fong, Luca Pignata, Pierre-Alexis Goy et al. · Cancer Cell · 2019 · 270 citations · Full text

Rna Processing, Transcriptional Regulation, Engineering +13