Catch-bond mechanism of the bacterial adhesin FimH

Maximilian M. Sauer, Roman P. Jakob, Jonathan Eras, +7

Nature Communications

FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile

Simon Kleeb, Lijuan Pang, Katharina Mayer, +18

Journal of Medicinal Chemistry

Vivo Pk/pd ProfileEngineeringAntibiotic AdjuvantPharmacotherapyAntimicrobial Chemotherapy +21

Combining High‐Throughput Synthesis and High‐Throughput Protein Crystallography for Accelerated Hit Identification

Fandi Sutanto, Shabnam Shaabani, Rick Oerlemans, +7

Angewandte Chemie International Edition

Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?

Katharina Mayer, Deniz Eriş, Oliver Schwardt, +4

Journal of Medicinal Chemistry

Urinary Tract InfectionDrug ResistanceFrequent Antibiotic TreatmentAntimicrobial ResistanceHealth Sciences +17

Target‐directed Dynamic Combinatorial Chemistry: A Study on Potentials and Pitfalls as Exemplified on a Bacterial Target

Priska Frei, Lijuan Pang, Marleen Silbermann, +4

Chemistry - A European Journal

Drug TargetBioorganic ChemistryBacteriologyDynamic Library ConstituentsChemical Biology +17

Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system

Said Rabbani, Brigitte Fiege, Deniz Eriş, +5

Journal of Biological Chemistry

Protein AssemblyPilin DomainBacteriologyMolecular BiologyMinimalistic Allosteric System +17

Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity

Chao Gao, Kathrin Stavenhagen, Barbara Eckmair, +12

Science Advances

The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target?

Deniz Eriş, Roland C. Preston, Meike Scharenberg, +6

ChemBioChem

Probing ligand binding of endothiapepsin by `temperature-resolved' macromolecular crystallography

Chia‐Ying Huang, Sylvain Aumonier, Sylvain Engilberge, +11

Acta Crystallographica Section D Structural Biology

BiochemistryProtein AssemblyProtein FoldingDa FragmentNatural Sciences +12

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

Chia‐Ying Huang, A. Metz, Roland Lange, +12

Acta Crystallographica Section D Structural Biology