Targeting GLP-1 receptor trafficking to improve agonist efficacy

Ben Jones, Teresa Buenaventura, Nisha Kanda, +18

Nature Communications

Glp-1 Receptor TraffickingImmunologyPharmacotherapyGlp-1r InternalizationInsulin Signaling +19

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia

Lan Zhao, Eduardo Oliver, Klio Maratou, +17

Nature

Pulmonary CirculationLung InflammationPhysiologyHypoxia (Medicine)Pulmonary Physiology +7

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoît Hastoy, +43

Nature Genetics

Metabolic SyndromeInsulin SignalingSignal TransductionEnhanced Insulin SecretionPhysiology +8

An essential role for the Zn2+ transporter ZIP7 in B cell development

Consuelo Anzilotti, David Swan, Bertrand Boisson, +42

Nature Immunology

Developmental BiologyEssential RoleCell SignalingImmune Cell DevelopmentB Cell Development +7

Mitochondrial and ER-Targeted eCALWY Probes Reveal High Levels of Free Zn²⁺

Pauline Chabosseau, Erkan Tuncay, Gargi Meur, +10

ACS Chemical Biology

Zn2+ MobilizationMolecular BiologyMitochondrial BiologyRedox BiologyCellular Physiology +18

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome

Yonatan Perez, Zamir Shorer, Keren Liani-Leibson, +13

Brain

Glomerular DiseaseGeneticsRenal PathologyGenetic EpidemiologyRenal Inflammation +26

eZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn²⁺ Imaging

Anne M. Hessels, Pauline Chabosseau, Maarten H. Bakker, +3

ACS Chemical Biology

Cytosolic Free ZnSignal TransductionSignaling PathwayNatural SciencesMolecular Biology +12

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome

Pauline Chabosseau, Géraldine Buhagiar‐Labarchède, Rosine Onclercq-Delic, +4

Nature Communications

BiologyGenome InstabilityBlm Helicase DeficiencyGenetic DisorderNatural Sciences +7

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

Guy A. Rutter, Pauline Chabosseau, Elisa A. Bellomo, +5

Proceedings of The Nutrition Society

NutritionGlucose HomeostasisInsulin SignalingMetabolic SyndromeZn2+ Ions +19

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Gaëlle Carrat, Ming Hu, Marie‐Sophie Nguyen‐Tu, +23

The American Journal of Human Genetics