Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

James Lally, Sarani Ghoshal, Danielle K. DePeralta, +32

Cell Metabolism

OxysterolBiochemistryMedicineLiver PhysiologyAcetyl-coa Carboxylase +6

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

Goichi Yoshimoto, Toshihiro Miyamoto, Siamak Jabbarzadeh‐Tabrizi, +12

Blood

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD

Jennifer L. Rocnik, Rachel Okabe, Jin‐Chen Yu, +4

Blood

Structural and numerical variation of FLT3/ITD in pediatric AML

Soheil Meshinchi, Derek L. Stirewalt, Todd A. Alonzo, +6

Blood

Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

Timothy R. Wagenaar, Sonya Zabludoff, Sung‐Min Ahn, +25

Molecular Cancer Research

TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation

Zineb Mounir, Fallon Lin, Virginia Lin, +13

Oncogene

UrologySignal TransductionHormonal ReceptorErg BlocksLuminal Cell Differentiation +7

Kinase Activation and Transformation by NUP214-ABL1 Is Dependent on the Context of the Nuclear Pore

Kim De Keersmaecker, Jennifer L. Rocnik, Rafael Bernad, +10

Molecular Cell

ChromatinSignal TransductionNatural SciencesReceptor Tyrosine KinaseNuclear Pore +10

PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene

Zhuyan Guo, Anlai Wang, Weidong Zhang, +19

Blood

Anti‐leukaemic activity of the TYK2 selective inhibitor NDI‐031301 in T‐cell acute lymphoblastic leukaemia

Koshi Akahane, Zhaodong Li, Julia Etchin, +11

British Journal of Haematology

Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches

Qiang Gao, I. Mechin, Nayantara Kothari, +22

Journal of Biological Chemistry

Cancer DependenceStructural ApproachesMedicineReceptor Tyrosine KinaseProtein Phosphorylation +7