Expression of Jak2V617F causes a polycythemia vera–like disease with associated myelofibrosis in a murine bone marrow transplant model

Gerlinde Wernig, Thomas Mercher, Rachel Okabe, +3

Blood

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Michael G. Kharas, Christopher J. Lengner, Fátima Al‐Shahrour, +17

Nature Medicine

Hematological MalignancyHematologyMedicineCell BiologyTumor Biology +1

Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells

Ann Mullally, Steven Lane, Brian Ball, +13

Cancer Cell

Progenitor CellsHematological MalignancyMedicineMalignant Blood DisorderImmunology +11

Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera

Gerlinde Wernig, Michael G. Kharas, Rachel Okabe, +16

Cancer Cell

MedicineJak2v617f-induced Polycythemia VeraMurine ModelImmunologyHematology +6

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Michael G. Kharas, Rachel Okabe, Jared J. Ganis, +5

Blood

PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

Jing Chen, Daniel J. DeAngelo, Jeffery L. Kutok, +20

Proceedings of the National Academy of Sciences

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

Inga Hofmann, Elizabeth H. Stover, Dana E. Cullen, +13

Cell stem cell

Induced Pluripotent Stem CellDevelopmental BiologyHedgehog SignalingMedicineStem Cell Mobilization +6

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD

Jennifer L. Rocnik, Rachel Okabe, Jin‐Chen Yu, +4

Blood

FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

Jing Chen, Benjamin H. Lee, Ifor R. Williams, +13

Oncogene

Hematopoietic MalignanciesHematological MalignancyMedicineMalignant Blood DisorderPathology +5

Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias

Brynn T. Kvinlaug, Wai-In Chan, Lars Bullinger, +14

Cancer Research

Hematological MalignancyChromatinSystems BiologyMixed-phenotype Acute LeukemiaGenetics +12