Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew, Josephine R. Giles, Amy E. Baxter, +33

Science

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis, +31

Science

Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes, M. Betina Pampena, Wenzhao Meng, +28

Science Immunology

ImmunologyPathologyImmunologic MechanismCovid-19 EpidemiologyImmune System +15

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

Rishi R. Goel, Sokratis A. Apostolidis, Mark M. Painter, +28

Science Immunology

VaccinationImmunological MemoryDistinct AntibodyVaccine DevelopmentVaccine Target +13

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

Mark M. Painter, Divij Mathew, Rishi R. Goel, +29

Immunity

VaccinationVaccine DevelopmentRapid InductionAdaptive Immune SystemSars-cov-2 Mrna Vaccination +9

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

Elizabeth M. Anderson, Eileen C. Goodwin, Anurag Verma, +35

Cell

VaccinationSars-cov-2 InfectionCovid-19 PandemicViral PathogenesisImmunology +5

Human CD4 ⁺ CD103 ⁺ cutaneous resident memory T cells are found in the circulation of healthy individuals

Maria M. Klicznik, Peter A. Morawski, Barbara Höllbacher, +11

Science Immunology

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

Laura A. Vella, Josephine R. Giles, Amy E. Baxter, +28

Science Immunology

Clinical ImmunologyImmunodeficienciesDeep Immune ProfilingImmunologyImmune Regulation +20

CTLA-4+PD-1− Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

Colleen S. McGary, Claire Deléage, Justin Harper, +14

Immunity

Identification and characterization of HIV-specific resident memory CD8 ⁺ T cells in human lymphoid tissue

Marcus Buggert, Son Nguyen, Gonzalo Salgado-Montes de, +37

Science Immunology