Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Maria Frank-Kamenetsky, Xiaoyan M. Zhang, Steve Bottega, +9

Journal of Biology

Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

Juliet Williams, Oivin Guicherit, Beatrice I. Zaharian, +8

Proceedings of the National Academy of Sciences

Signaling PathwayOncogenic AgentMedicineBcc Model SystemsSmall Molecule Inhibitor +9

Transcriptional Control

Fábio Rossi, Andrew M. Kringstein, Albert Spicher, +2

Molecular Cell

Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16

Fábio Rossi, Oivin Guicherit, Albert Spicher, +4

Nature Genetics

Cell RegulationBiochemistryMolecular RegulationNatural SciencesReversible Growth Inhibition +6

Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures

Oksana Sirenko, Fred Parham, Steven Dea, +12

Toxicological Sciences

Calcium Oscillation RateCerebral OrganoidBiomedical EngineeringCellular NeurobiologySocial Sciences +15

Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Pei‐Pei Kung, Ricardo Martínez, Zhou Zhu, +18

Molecular Cancer Therapeutics

Breast OncologyCancer BiologyTumor BiologySpindle Assembly CheckpointBreast Cancer Patients +16

Highly Conserved RNA Sequences That Are Sensors of Environmental Stress

Albert Spicher, Oivin Guicherit, Laurent Duret, +5

Molecular and Cellular Biology

IFNα induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling

Chengxin Li, Sumin Chi, Nonggao He, +5

Oncogene

Signal TransductionBcc CellsSignaling PathwayHedgehog PathwayCell Regulation +8

The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine.

Khalid A. Mohamedali, Oivin Guicherit, Rodney E. Kellems, +1

Journal of Biological Chemistry

GeneticsGastroenterologyProximal Small IntestineDigestive TractUric Acid +16

Potent Inhibitors of the Hedgehog Signaling Pathway

Shirley A. Brunton, J. H. A. STIBBARD, Lee L. Rubin, +4

Journal of Medicinal Chemistry

Signal TransductionSignaling PathwayBiochemistryMedicineReceptor Tyrosine Kinase +9