Bioanalysis of Antibody–Drug Conjugates: American Association of Pharmaceutical Scientists Antibody–Drug Conjugate Working Group Position Paper

Boris Gorovits, Stephen C. Alley, Sanela Bilic, +7

Bioanalysis

American AssociationImmunologyMedicinal ChemistryBioanalysisImmunochemistry +15

A Phase <scp>IB</scp> multicentre dose‐determination study of <scp>BHQ</scp>880 in combination with anti‐myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal‐related events

Swaminathan P. Iyer, Joseph Taddeus Beck, A. Keith Stewart, +6

British Journal of Haematology

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

Seth A. Ettenberg, Olga Charlat, Shanming Liu, +23

Proceedings of the National Academy of Sciences

Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor

Kyriakos P. Papadopoulos, Randi Isaacs, Sanela Bilic, +8

Cancer Chemotherapy and Pharmacology

NanomedicineDrug TargetDrug TargetingDr5 ReceptorBiochemistry +7

Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia

John C. Byrd, Thomas J. Kipps, Ian W. Flinn, +8

Leukemia & lymphoma/Leukemia and lymphoma

Chronic Lymphocytic LeukemiaImmunologyAnti-cd40 AntibodyPathologyPharmacotherapy +16

A phase 1 study of lucatumumab, a fully human anti‐<scp>CD</scp>40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma

William Bensinger, Richard T. Maziarz, Sundar Jagannath, +8

British Journal of Haematology

Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction

Heather Huet, Joseph D. Growney, Jennifer Johnson, +18

mAbs

NanotherapeuticsEngineeringImmunologyCell DeathImmunotherapeutics +23

Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones

Elena Denisenko, Leanne de Kock, Adeline Tan, +19

Nature Communications

A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

Nicola S. Meagher, Linyuan Wang, Peter Rambau, +79

Modern Pathology

Tumoral PathologyAppendiceal MetastasesMedicineGynecologyPathology +5

Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome

Gail J. Roboz, Francis J. Giles, Alan F. List, +9

Leukemia

Hematological MalignancyPtk787/zk 222584MedicineAcute Myeloid LeukemiaReceptor Tyrosine Kinase +7