Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Yongneng Zhang, Tetsuya Yamamoto, Ichiro Hisatome, +10

Molecular and Cellular Endocrinology

Cell PhysiologySignal TransductionPhysiologyGrowth InhibitionPancreatic β Cells +7

Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Emodin

Xubin Jing, Noboru Ueki, Jidong Cheng, +2

Japanese Journal of Cancer Research

Lipid PeroxidationApoptosisCell DeathPathologyRedox Biology +18

Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo

Xianbin Cai, Xi Hu, Xiaojun Tan, +6

PLoS ONE

Esophageal CancerCell DeathPathologyCell ProliferationMetabolic Remodeling +14

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

Jidong Cheng, Tianliang Huang, Youfeng Li, +10

PLoS ONE

Ampk ActivityVivo ProliferationInsulin SignalingTumor BiologyAmp-activated Protein Kinase +18

Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo

Xianbin Cai, Xi Hu, Bozhi Cai, +8

Oncology Reports

Reactive oxygen species and mitochondrial membrane potential are modulated during CDDP-induced apoptosis in EC-109 cellsThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process.

Xubin Jing, Xianbin Cai, Hui Hu, +3

Biochemistry and Cell Biology

Fecal microbiota transplantation treatment for type 1 diabetes mellitus with malnutrition: a case report

Yanchun Xie, Xubin Jing, Xiang Chen, +3

Therapeutic Advances in Chronic Disease

DysbiosisImmunologyGastroenterologyPathologyGut Microbiota +15

Suppressing Cyclooxygenase-2 Prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway

Jialing Wu, Chong Chen, Xi Hu, +7

Biochemical and Biophysical Research Communications

Cyclooxygenase-2 PreventsInhibits ApoptosisHepatologyChemoprevention StrategyMedicine +10

Apoptosis induced by emodin is associated with alterations of intracellular acidification and reactive oxygen species in EC-109 cellsThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

Q. J. Wang, Xianbin Cai, Meng-Syuan Liu, +3

Biochemistry and Cell Biology

ApoptosisCell DeathCell Death MechanismsReactive Oxygen SpeciesRedox Biology +18

Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway

Yindi He, Xiaojun Tan, Hui Hu, +6

Oncology Letters