Michelle Kasem

(1a<i>R</i>,5a<i>R</i>)1a,3,5,5a-Tetrahydro-1<i>H</i>-2,3-diaza-cyclopropa[<i>a</i>]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

P. Douglas Boatman, Brett Lauring, Thomas O. Schrader et al. · Journal of Medicinal Chemistry · 2012 · 50 citations · Full text

Pharmacotherapy, Pharmaceutical Chemistry, Molecular Pharmacology +17

Complementary Asymmetric Routes to (<i>R</i>)-2-(7-Hydroxy-2,3-dihydro-1<i>H</i>-pyrrolo[1,2-<i>a</i>]indol-1-yl)acetate

Thomas O. Schrader, Benjamin Johnson, Luis Lopez et al. · Organic Letters · 2012 · 35 citations

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

P. Douglas Boatman, Thomas O. Schrader, Michelle Kasem et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 32 citations · Full text

Biochemistry, Functional Selectivity, Medicine +7

Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor

Daniel J. Buzard, Thomas O. Schrader, Xiuwen Zhu et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 18 citations · Full text

New Tricyclic Indoles, Biochemistry, Functional Selectivity +5

(7-Benzyloxy-2,3-dihydro-<i>1H</i>-pyrrolo[1,2-<i>a</i>]indol-1-yl)acetic Acids as S1P₁ Functional Antagonists

Daniel J. Buzard, Luis Lopez, Jeanne Moody et al. · ACS Medicinal Chemistry Letters · 2014 · 16 citations · Full text

S1p1 Functional Antagonists, Molecular Pharmacology, Medicinal Chemistry +15