D A Cahill

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao‐Jian Sun, Paul Rothenberg, C. Ronald Kahn et al. · Nature · 1991 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +14

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

Jonathan Backer, Gregory G. Schroeder, C. Ronald Kahn et al. · Journal of Biological Chemistry · 1992 · 149 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

Jonathan Backer, C. Ronald Kahn, D A Cahill et al. · Journal of Biological Chemistry · 1990 · 132 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

Peter A. Wilden, Jonathan Backer, C. Ronald Kahn et al. · Proceedings of the National Academy of Sciences · 1990 · 109 citations

Life Sciences, Biochemistry, Molecular Biology +16

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells

Jonathan Backer, Gregory G. Schroeder, D A Cahill et al. · Biochemistry · 1991 · 39 citations

Life Sciences, Biochemistry, Endocrinology +17