Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

Hannah N. Bell, Amanda K. Huber, Rashi Singhal, +23

Cell Metabolism

Cancer ImmunosurveillanceColorectal CancerMedicineCell BiologyTumor Microenvironment +1

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Andrew J. Schwartz, Joshua Goyert, Sumeet Solanki, +14

Nature Metabolism

Mitochondrial FunctionBiochemistryIron MetabolismLiver PhysiologySelenium Deficiency +10

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Samuel A. Kerk, Lin Lin, Amy L. Myers, +28

eLife

PathologyEnvironmental ContextMetabolic RemodelingRedox HomeostasisTumor Biology +21

MFSD12 mediates the import of cysteine into melanosomes and lysosomes

Charles H. Adelmann, Anna K. Traunbauer, Brandon Chen, +5

Nature

Protein FunctionSignal TransductionBiochemistryNatural SciencesMolecular Biology +7

Strengthening in Graphene Oxide Nanosheets: Bridging the Gap between Interplanar and Intraplanar Fracture

Changhong Cao, Matthew Daly, Brandon Chen, +4

Nano Letters

Materials ScienceGraphene NanomeshesBrittle FractureNanosheetIntraplanar Fracture +13

Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury

Hong‐Ru Chen, Ching‐Wen Chen, Yi-Min Kuo, +7

Theranostics

Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer

Meenal Sinha, Li Zhang, Sumit K. Subudhi, +14

Journal for ImmunoTherapy of Cancer

Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function

Chiara Rancan, Marcel Arias-Badia, Pranay Dogra, +13

Nature Immunology

Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction

Qiuyu Sun, Berna Güven, Cory S. Wagg, +13

Cardiovascular Research

Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress

Samantha N. Devenport, Rashi Singhal, Megan D. Radyk, +14

JCI Insight